Domigan, Courtney K.

Courtney is a third year trainee and is in the Department of Molecular, Cell and Developmental Biology.  Her research mentor is Dr. Luisa Iruela-Arispe.  She received a B.S. degree in 2007 from UC Santa Cruz. 

Mentor: Dr. Luisa Iruela-Arispe

Research project:

We are interested in the role vascular endothelial growth factor (VEGF) plays as an intracrine growth factor in both vascular development and adult homeostasis. We will address the role of VEGF in development using a chimeric mouse model which will allow us to determine when and where VEGF is required in a cell autonomous manner during development. To address the role of VEGF in adult endothelial homeostasis, the cellular localization of VEGF and subsequent downstream signaling pathways will be elucidated in homeostatic and stress conditions.