Erde, Jonathan

Jonathan is a second year trainee and is in the Department of Chemistry and Biochemistry.  His research mentor is Dr. Joseph Loo.  He received a B.S. degree in 2007 from Loyola Marymount University.

Mentor: Dr. Joseph Loo

Research project:

Ataxia Telangiectasia, Mutated (ATM) is a nuclear protein kinase at the core of the cellular response to double-stranded DNA breaks induced by ionizing radiation (IR).  Loss of functional ATM results in neurodegeneration, cancer predisposition and sensitivity to IR. I am currently employing Stable Isotope Labelling by Amino Acids in Cell Culture (SILAC) in order to study DNA damage repair following IR insult in lymphoblastoid cell lines (LCLs) with functional or aberrant ATM.  SILAC-based quantitative proteomics will provide a first look at the effects of IR on protein expression.  In the future this quantitative proteomic approach will be utilized to explore the cellular effects of potential radioprotector compounds in LCLs.