Maland, Matthew D. (2011-2014)
Matt is in the Department of Chemistry and Biochemistry. He joined the Training Program in 2011. His research mentor is Dr. Carla Koehler. He received a B.S. degree in 2010 from CSU Long Beach.
Mentor: Dr. Carla Koehler
The sulfhydryl oxidase Erv1 and oxidoreductase Mia40 mediate the import of disulfide proteins into the mitochondrial inner membrane space using thiol exchange reactions. This pathway is conserved from yeast to man and mutations in Erv1 result in cardiomyopathy. Moreover, Erv1 is a pro-survival factor in human embryonic stem cells. My hypothesis is that Erv1 and the redox regulated import pathway has an unexpected but essential role during development. I propose to develop new approaches to characterize the function of Erv1 yeast and mammalian systems.
