Rau, Christoph D.

Christoph is a third year trainee and is in the Department of Microbiology, Immunology and Molecular Genetics.  His research mentor is Dr. Jake Lusis.  He received a B.S. degree in 2007 from Harvey Mudd College.

Mentor: Dr. Jake Lusis

Research project:

Doxorubicin is a chemotherapy drug used to combat a number of cancers, including carcinomas and soft tissue sarcomas.  Although it is a very effective drug, it has a side effect of causing cardiotoxicity if a dose above the standard approved dose is administered.  Research done in the early 90s pointed to a genetic component to the cardiotoxicity, and a few genes were putatively identified.  My project is to use the resources of the Lusis Lab, especially their mouse diversity panel and computational resources to identify additional genes that are involved in this effect.